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Vaccine Detail

Brucella abortus pgk mutant vaccine
Vaccine Information
  • Vaccine Name: Brucella abortus pgk mutant vaccine
  • Target Pathogen: Brucella spp.
  • Target Disease: Brucellosis
  • Vaccine Ontology ID: VO_0002818
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • pgk gene engineering:
    • Type: Gene mutation
    • Description: This pgk mutant is from Brucella abortus strain 2308 (Trant et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Persistence: A pgk mutant is attenuated in mice (Trant et al., 2010).
  • Efficacy: A pgk mutant induces significant protection from challenge with wild type B. abortus (Trant et al., 2010).
  • Host Ifng (Interferon gamma) response
    • Description: In IRF-1 KO mice, significantly increased levels of IFN-gamma were produced after vaccination with a pgk mutant as compared to medium. Animals immunized with strain RB51 showed reduced production of IFN-γ compared to mice vaccinated with the Δpgk mutant and S19, but it was not a statistically significant difference (Trant et al., 2010).
    • Detailed Gene Information: Click Here.
References
Trant et al., 2010: Trant CG, Lacerda TL, Carvalho NB, Azevedo V, Rosinha GM, Salcedo SP, Gorvel JP, Oliveira SC. The Brucella abortus phosphoglycerate kinase mutant is highly attenuated and induces protection superior to that of vaccine strain 19 in immunocompromised and immunocompetent mice. Infection and immunity. 2010; 78(5); 2283-2291. [PubMed: 20194591].