VIOLIN: Vaccine Investigation and Online Information Network

G

General Information

Protegen ID

1671

Sequence Strain (Species/Organism)

Human respiratory syncytial virus A strain Long

Taxonomy ID

11260

Other Database IDs

CDD:144411
CDD:224196

Molecule Role

Protective antigen

Molecule Role Annotation

(Tripp et al., 2018)The G protein modulates neonatal regulatory B lymphocytes (nBreg cells) to produce immunosuppressive interleukin-10 (IL-10).

Related Vaccines(s)

HRSV DNA vaccine pND-G , MVA - RSV , rB-HPIV3-F1 , rB-HPIV3-G1 , rBPIV3-RSV-G , rVSV-Gstem-RSV-F , VSV-RSV(F/G)

References

Tripp et al., 2018: Tripp RA, Power UF, Openshaw PJM, Kauvar LM. Respiratory Syncytial Virus: Targeting the G Protein Provides a New Approach for an Old Problem. Journal of virology. 2018; 92(3); . [PubMed: 29118126].

Gene Information

Gene Name

Protein Information

Protein Name

Major surface glycoprotein G

NCBI Protein GI

1353203

Protein pI

10.72

Protein Weight

34785.98

Protein Length

465

Protein Note

Attachment glycoprotein G; Membrane-bound glycoprotein; mG

Protein Sequence

>sp|P20895.2|GLYC_HRSVL RecName: Full=Major surface glycoprotein G; AltName: Full=Attachment glycoprotein G; AltName: Full=Membrane-bound glycoprotein; Short=mG
MSKNKDQRTAKTLEKTWDTLNHLLFISSGLYKLNLKSIAQITLSILAMIISTSLIITAIIFIASANHKVT
LTTAIIQDATSQIKNTTPTYLTQDPQLGISFSNLSEITSQTTTILASTTPGVKSNLQPTTVKTKNTTTTQ
TQPSKPTTKQRQNKPPNKPNNDFHFEVFNFVPCSICSNNPTCWAICKRIPNKKPGKKTTTKPTKKPTFKT
TKKDHKPQTTKPKEVPTTKPTEEPTINTTKTNIITTLLTNNTTGNPKLTSQMETFHSTSSEGNLSPSQVS
TTSEHPSQPSSPPNTTRQ

Epitope Information

IEDB Linear Epitope