VIOLIN: Vaccine Investigation and Online Information Network

NP from Lake Victoria marburgvirus

General Information

Protegen ID

573

Sequence Strain (Species/Organism)

Lake Victoria marburgvirus

VO ID

VO_0011163

Taxonomy ID

11269

Other Database IDs

CDD:283221
CDD:274446

Molecule Role

Protective antigen

Molecule Role Annotation

Nonhuman primates (cynomolgus macaques) were inoculated with VEE replicons expressing MBGV GP and/or NP and challenged with MGBV. MBGV NP afforded incomplete (partial) protection, sufficient to prevent death but not disease in two of three macaques (Hevey et al., 1998).

Related Vaccines(s)

Marburg Virus Nucleoprotein Vaccine , Marburg virus recombinant vector vaccine MBGV GP

References

Hevey et al., 1998: Hevey M, Negley D, Pushko P, Smith J, Schmaljohn A. Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates. Virology. 1998 Nov 10; 251(1); 28-37. [PubMed: 9813200 ].

Gene Information

Gene Name

NP from Lake Victoria marburgvirus

Protein Information

Protein Name

nucleoprotein

NCBI Protein GI

332181

Protein pI

4.71

Protein Weight

73740.44

Protein Length

755

Protein Note

Ebola nucleoprotein; pfam05505

Protein Sequence

>AAA46563.1 nucleoprotein [Marburg marburgvirus]
MDLHSLLELGTKPTAPHVRNKKVILFDTNHQVSICNQIIDAINSGIDLGDLLEGGLLTLCVEHYYNSDKD
KFNTSPVAKYLRDAGYEFDVIKNADATRFLDVSPNEPHYSPLILALKTLESTESQRGRIGLFLSFCSLFL
PKLVVGDRASIEKALRQVTVHQEQGIVTYPNHWLTTGHMKVIFGILRSSFILKFVLIHQGVNLVTGHDAY
DSIISNSVGQTRFSGLLIVKTVLEFILQKTDSGVTLHPLVRTSKVKNEVASFKQALSNLARHGEYAPFAR
VLNLSGINNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAAHDAEVKLQRRHEHQEIQAIAE
DDEERKILEQFHLQKTEITHSQTLAVLSQKREKLARLAAEIENNIVEDQGFKQSQNRVSQSFLNDPTPVE
VTVQARPMNRPTALPPPVDDKIEHESTEDSSSSSSFVDLNDPFALLNEDEDTLDDSVMIPGTTSREFQGI
PEPPRQSQDLNNSQGKQEDESTNRIKKQFLRYQELPPVQEDDESEYTTDSQESIDQPGSDNEQGVDLPPP
PLYAQEKRQDPIQHPAANPQDPFGSIGDVNGDILEPIRSPSSPSAPQEDTRMREAYELSPDFTNDEDNQQ
NWPQRVVTKKGRTFLYPNDLLQTNPPESLITALVEEYQNPVSAKELQADWPDMSFDERRHVAMNL

Epitope Information

IEDB Linear Epitope