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cna

General Information
Protegen ID 846
Sequence Strain (Species/Organism) Staphylococcus aureus
VO ID VO_0012389
Taxonomy ID 1280
Other Database IDs CDD:283410
CDD:283411
CDD:301706
CDD:212461
Molecule Role Protective antigen
Molecule Role Annotation Mice were immunized with a recombinant fragment of CNA protein, and were then challenged with the S. aureus clinical isolate strain Phillips. At 14 d after inoculation, mortality in the collagen adhesin-vaccinated group was only 13%, compared with 87% in the control antigen immunized group (Nilsson et al., 1998).
Mice vaccinated with a combination of two Staphylococcus aureus antigens consisting of a recombinant collagen-binding protein (CnBP) and alpha-toxoid (alpha-toxoid) were significantly protected from intramammary challenge infection with S. aureus.(Mamo et al., 2000)
Related Vaccines(s) S. aureus CNA Protein Vaccine , S. aureus DNA vaccine encoding Efb, FnbpA, ClfA, Cna
References
Mamo et al., 2000: Mamo W, Fröman G, Müller HP. Protection induced in mice vaccinated with recombinant collagen-binding protein (CnBP) and alpha-toxoid against intramammary infection with Staphylococcus aureus. Microbiology and immunology. 2000; 44(5); 381-384. [PubMed: 10888356].
Nilsson et al., 1998: Nilsson IM, Patti JM, Bremell T, Höök M, Tarkowski A. Vaccination with a recombinant fragment of collagen adhesin provides protection against Staphylococcus aureus-mediated septic death. The Journal of clinical investigation. 1998; 101(12); 2640-2649. [PubMed: 9637697].
Gene Information
Gene Name cna
NCBI Nucleotide GI 387879
DNA Sequence 
>gi|387879|gb|M81736.1|STACNA Staphylococcus aureus collagen adhesin (cna) gene, complete cds
ATGCACTTGTATTCGTTATACTGTATATATTTTGCATAATAAAATAATAATATGAATTTTTGATAAATTT
CATTGAATAAGAACTAAATTAGTTTATAATTTATTATTAGTATCCTGTGGATATGACATAGAGTATAAGG
AGGGGTTTTTATGAACAAAAATGTGTTGAAGTTTATGGTCTTTATAATGTTATTAAATATCATCACACCT
TTATTTAATAAAAATGAAGCATTTGCAGCACGAGATATTTCATCAACGAATGTTACAGATTTAACTGTAT
CACCGTCTAAGATAGAAGATGGTGGTAAAACGACAGTAAAAATGACGTTCGACGATAAAAATGGAAAAAT
ACAAAATGGTGACATGATTAAAGTGGCATGGCCGACAAGCGGTACAGTAAAGATAGAGGGTTATAGTAAA
ACAGTACCATTAACTGTTAAAGGTGAACAGGTGGGTCAAGCAGTTATTACACCAGACGGTGCAACAATTA
CATTCAATGATAAAGTAGAAAAATTAAGTGATGTTTCGGGATTTGCAGAATTTGAAGTACAAGGAAGAAA
TTTAACGCAAACAAATACTTCAGATGACAAAGTAGCTACGATAACATCTGGGAATAAATCAACGAATGTT
ACGGTTCATAAAAGTGAAGCGGGAACAAGTAGTGTTTTCTATTATAAAACGGGAGATATGCTACCAGAAG
ATACGACACATGTACGATGGTTTTTAAATATTAACAATGAAAAAAGTTATGTATCGAAAGATATTACTAT
AAAGGATCAGATTCAAGGTGGACAGCAGTTAGATTTAAGCACATTAAACATTAATGTGACAGGTACACAT
AGCAATTATTATAGTGGACAAAGTGCAATTACTGATTTTGAAAAAGCCTTTCCAGGTTCTAAAATAACTG
TTGATAATACGAAGAACACAATTGATGTAACAATTCCACAAGGCTATGGGTCATATAATAGTTTTTCAAT
TAACTACAAAACCAAAATTACGAATGAACAGCAAAAAGAGTTTGTTAATAATTCACAAGCTTGGTATCAA
GAGCATGGTAAGGAAGAAGTGAACGGGAAATCATTTAATCATACTGTGCACAATATTAATGCTAATGCCG
GTATTGAAGGTACTGTAAAAGGTGAATTAAAAGTTTTAAAACAGGATAAAGATACCAAGGCTCCTATAGC
TAATGTAAAATTTAAACTTTCTAAAAAAGATGGATCAGTTGTAAAGGACAATCAAAAAGAAATTGAGATT
ATAACAGATGCAAACGGTATTGCTAATATTAAAGCGTTGCCTAGTGGAGACTATATTTTAAAAGAAATAG
AGGCGCCACGACCGTATACATTTGATAAGGATAAAGAATATCCGTTTACTATGAAAGATACAGATAATCA
GGGATATTTTACGACTATTGAAAATGCAAAAGCGATAGAAAAAACAAAAGATGTTTCTGCTCAAAAGGTT
TGGGAAGGCACTCAAAAAGTGAAACCAACGATTTATTTCAAGTTGTACAAACAAGATGACAATCAAAATA
CAACACCAGTAGACAAAGCAGAGATTAAAAAATTAGAAGATGGAACGACAAAAGTGACATGGTCTAATCT
TCCGGAAAATGACAAAAATGGCAAGGCTATTAAATATTTAGTTAAAGAAGTAAATGCTCAAGGTGAAGAT
ACAACACCAGAAGGATATACTAAAAAAGAAAATGGTTTAGTGGTTACTAATACTGAAAAACCAATCGAAA
CAACATCAATTAGTGGTGAAAAAGTATGGGACGACAAAGACAATCAAGATGGTAAGAGACCAGAAAAAGT
CAGTGTGAATTTATTGGCTAACGGGGAGAAAGTAAAAACGTTAGACGTGACATCTGAAACAAACTGGAAG
TACGAATTTAAAGACTTACCGAAGTATGATGAAGGAAAGAAAATAGAATATACAGTGACCGAAGATCACG
TAAAAGACTACACAACAGACATCAACGGTACGACAATAACGAACAAGTATACACCAGGAGAGACATCGGC
AACAGTAACAAAAAATTGGGATGACAATAATAACCAAGACGGAAAACGACCAACTGAAATCAAAGTTGAG
TTATATCAAGATGGAAAAGCAACAGGAAAAACGGCAATATTAAATGAATCTAATAACTGGACACATACGT
GGACAGGATTAGATGAAAAAGCAAAAGGACAACAAGTAAAATACACAGTCGAGGAATTAACAAAGGTCAA
AGGTTATACAACACATGTGGATAACAATGATATGGGTAACTTGATTGTGACGAATAAATATACGCCAGAA
ACAACATCAATTAGTGGTGAAAAAGTATGGGACGACAAAGACAATCAAGATGGTAAGAGACCAGAAAAAG
TCAGTGTGAATTTATTGGCTGATGGAGAGAAAGTAAAAACGTTAGACGTGACATCTGAAACAAACTGGAA
GTACGAATTTAAAGACTTACCGAAGTATGATGAAGGAAAGAAAATAGAATATACAGTGACCGAAGATCAC
GTAAAAGACTACACAACAGACATCAACGGTACGACAATAACGAACAAGTATACACCAGGAGAGACATCGG
CAACAGTAACAAAAAATTGGGATGACAATAATAACCAAGACGGAAAACGACCAACTGAAATCAAAGTTGA
GTTATATCAAGATGGAAAAGCAACAGGAAAAACGGCAATATTAAATGAATCTAATAACTGGACACATACG
TGGACAGGATTAGATGAAAAAGCAAAAGGACAACAAGTAAAATACACAGTCGAGGAATTAACAAAGGTCA
AAGGTTATACAACACATGTGGATAACAATGATATGGGCAACTTGATTGTGACGAATAAATATACGCCAGA
AACAACATCAATTAGTGGTGAAAAAGTATGGGACGACAAAGACAATCAAGATGGTAAGAGACCAGAAAAA
GTCAGTGTGAATTTATTGGCTAACGGAGAGAAAGTAAAAACGTTAGACGTGACATCTGAAACAAACTGGA
AGTACGAATTTAAAGACTTACCGAAGTATGATGAAGGAAAGAAAATAGAATATACAGTGACCGAAGATCA
CGTAAAAGACTACACAACAGACATCAACGGTACGACAATAACGAACAAGTATACACCAGGAGAGACATCG
GCAACAGTAACAAAAAATTGGGATGACAATAATAACCAAGACGGAAAACGACCAACTGAAATCAAAGTTG
AGTTATATCAAGATGGAAAAGCAACAGGAAAAACGGCAATATTAAATGAATCTAATAACTGGACACATAC
GTGGACAGGATTAGATGAAAAAGCAAAAGGACAACAAGTAAAATACACAGTCGATGAATTAACAAAAGTT
AATGGCTATACAACGCATGTGGATAACAATGATATGGGTAACTTGATTGTGACAAATAAATATACGCCGA
AAAAACCGAATAAACCAATCTATCCTGAAAAACCAAAAGACAAAACACCACCAACTAAACCTGATCATTC
TAATAAAGTTAAACCAACTCCCCCAGATAAGCCATCAAAAGTGGATAAGGATGATCAACCTAAAGATAAT
AAAACCAAACCTGAAAATCCTCTAAAAGAATTACCAAAAACTGGTATGAAGATTATAACTTCATGGATTA
CATGGGTATTTATAGGTATATTGGGACTGTATTTAATTTTAAGAAAAAGATTTAACTCATAAACCATTAT
AATTATTTTTATAGATAAGGCTATTCTTAGTTCTATGTATAATACATGTATATTAATAGGTCACTTTTAA
TCTGTATGTAAGCAGACTAAGAGTGGCCTTTTAAACAAATAAAAAAA
Protein Information
Protein Name Cna B-type domain-containing protein
NCBI Protein GI WP_001039420
Protein Accession AAA20874.1
3D structure: PDB ID 2F68
Protein pI 6.09
Protein Weight 124972.57
Protein Length 1278
Protein Note Collagen binding domain; pfam05737
Protein Sequence 
>WP_001039420.1 Cna B-type domain-containing protein [Staphylococcus aureus]
MNKNVLKFMVFIMLLNIITPLFNKNEALAARDISSTNVTDLTVSPTKIEDGGKTTVKMTFDDKSVKIQNG
DTIKVAWPTSGTVKIEGYSKTVPLTVKGEQVGQAVITPDGATITFNDKVEKLSDVSGFAEFEVQGRNLTQ
TNTSDDKVATITSGNKSTNVTVHKSEAGTSSVFYYKTGDMLPEDTTHVRWFLNINNEKRYVSKDITIKDQ
IQGGQQLDLSTLNINVTGTHSNYYSGSNAITDFEKAFPGSKITVDNTKNTIDVTIPQGYGSYNSFSINYK
TKITNEQQKEFVNNSQAWYQEHGKEEVNGKSFNHTVHNINANAGIEGTVKGELKVLKQDKDTKAPIANVK
FKLSKKDGSVVKDNQKEIEIITDANGTANIKALPSGDYILKEIEAPAPYTFDKDKEYPFTMKDTDNQGYF
TTIENAKEIEKTKDVSAQKVWEGTQKVKPTIYFKLYKQDDNQNTTPVDKAEIKKLEDGTTKVTWSNLPEN
DKNGKTIKYLVKEVNAQGEDTTPEGYTKKENGLVVTNTEKPIETTSISGEKVWDDKDNQDGKRPEKVSVN
LLANGEKVKTLDVTSETNWKYEFKNLPKYDEGKKIEYTVTEDHVKDYTTDINGTTITNKYTPGETSATVT
KNWDDNNNQDGKRPTEIKVELYQDGKATGKTATLNESNNWTHTWAGLDEKAKGQQVKYTVEELTKVKGYT
THVDNNDMGNLIVTNKYTPETTSISGEKVWDDKDNQDGKRPEKVSVNLLANGEKVKAVDVTSETNWKYEF
KDLPKYDEGKKIEYTVTEDHVKDYTTDINGTTITNKYTPGETSATVTKNWDDNNNQDGKRPTEIKVELYQ
DGKATGKTAKLNESNNWTHTWTGLDEKAKGQQVKYTVEELTKVKGYTTHVDNNDMGNLIVTNKYTPETTS
INGEKVWDDKDNQDGKRPEKVSINLLANGEKVKTLDVTSETNWKYEFKDLPKYDEGKKIEYTVTEDHVKD
YTTDINGTTITNKYTPGETSATVTKNWDDNNNQDGKRPTEIKVELYQDGKATGKTATLNESNNWTHTWAG
LDEKAKGQQVKYTVEELTKVKGYTTHVDNNDMGNLIVTNKYTPEKPNKPIYPEKPKDKTPPTKPDHSNKV
KPTPPDKPSKVDKDDQPKDNKTKPENPLKELPKTGMKIITSWITWVFIGILGLYLILRKRFNS
Epitope Information
IEDB Linear Epitope